One of the slithering, genetically enhanced anaconda offspring has regenerated to live on in this next action-packed chapter of the Anaconda series. The dying mogul, Murdoch (John Rhys-Davies), hires a doctor to harvest a fresh supply of blood orchids and experiment with the regenerative nectar on a baby snake. Overnight, the offspring grows monstrous enough in size and appetite to devour the good doctor whole, before slithering free on a regenerative rampage. Beautiful herpetologist Amanda (Crystal Allen), dedicated to destroying the beasts she helped create, leads a team of young scientists against a pack of Murdoch's armed thugs to get the coveted orchids before the snake hunts both factions down. Seemingly invincible, the bloodthirsty reptile slips through explosions and gunfire only to regenerate and prey insatiably on anything in its path.